Granulocytes Apheresis, Irradiated
Granulocyte concentrates are prepared by leukapheresis of a single donor. Apheresis granulocytes normally contain a variable number of other leukocytes, platelets, and red blood cells, but the concentrate must contain at least 1.0 x1010 granulocytes. Apheresis granulocytes are used for severely granulocytopenic (neutropenic) patients with fever and infection who inadequately respond to antibiotic therapy. Granulocyte therapy may also be used in neonatal bacterial sepsis. The product is time sensitive since they can be stored for only 24 hours.