Laboratory of Membrane Biology Receives $875,000 Grant to Study Red Cell Production: Key Facets of Many Blood Diseases
LFKRI’s Laboratory of Membrane Biology has received a significant grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDKD) of the National Institutes of Health to develop a comprehensive mechanistic understanding of the regulation of terminal erythroid differentiation in the production of red blood cells in normal and disease states. Xiuli An MD, PhD, was awarded nearly $875,000 for this program, including a subcontract with the University of Michigan.
Dr. An anticipates that successful accomplishment of the proposed studies will lead to a better understanding of erythroid cell development and differentiation. Specifically, it is hoped that this project will validate the newly identified novel epigenetic regulatory pathway in erythroid biology and provide the basis for future high impact research endeavors. As aberrant DNA methylation underlies many hematological diseases it is likely that this finding may also provide novel insights into these diseases.