Hong Van Tieu, MD

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Title

Head, Laboratory of Infectious Disease Prevention
Associate Member, Lindsley F. Kimball Research Institute

Contact Information

Email: HTieu@nybc.org
Phone: +1 (212) 570-3081

Current Projects 

HIV Vaccine and Monoclonal Antibody Studies

In collaboration with the NIH/NIAID-funded HIV Vaccine Trials Network (HVTN) and with the Columbia Partnership for Prevention and Control of HIV/AIDS Clinical Trials Unit, this work involves implementation of multiple Phase 1-3 HIV vaccine research trials to test the safety, tolerability, and efficacy of HIV vaccine products and monoclonal antibodies to prevent HIV infection through our research site, Project ACHIEVE.

HIV Injectable Pre-Exposure Prophylaxis Study

In collaboration with the NIH/NIAID-funded HIV Prevention Trials Network (HPTN), this multi-site, multi-country study is a Phase 2/3 study comparing injectable cabotegravir to emtricitabine/tenofovir (FTC/TDF) for preventing HIV infection in men who have sex with men and transgender women.

Neighborhoods, Networks, and the HIV Care Continuum

This NIH/NIMH-funded two-phase research study involves a mixed methods approach to ascertain unique, salient neighborhood and network factors that influence HIV care continuum outcomes (retention in care, ART adherence, and viral suppression) among HIV-infected men who have sex with men in New York City using qualitative interviews and spatial analysis and multilevel modeling.

Pre-Exposure Prophylaxis in Women

This NIH R340-funded three-phase project seeks to develop and pilot an intervention to enhance uptake of pre-exposure prophylaxis (PrEP) among women at risk for HIV, and support adherence, and linkage to care in New York City and Philadelphia. Text based messaging will be used to encourage PrEP adherence, and the feasibility and acceptability of the intervention will be tested.

Hepatitis C Infections among Men Who Have Sex with Men

This research aims to determine  the prevalence of recent and chronic hepatitis C (HCV) infections among MSM in NYC, map HCV infections by home, social, and sexual neighborhoods, and determine clusters of genetically linked HCV variants among recently and chronically HCV-infected MSM in NYC using phylogenetic analysis.

Blood Donation in Men Who Have Sex with Men

A pilot study seeks to identify and describe motivations, barriers, and facilitators to blood donation among Black donors by analyzing YouTube video content. In addition, as a collaboration between the New York Blood Center, One Blood, and Blood Systems at UCSF, an NIH grant proposal has been submitted to evaluate the impact of the change to a 1-year deferral from blood donation for men who have sex with men in five diverse regions of the US. The project is a mixed-methods study in three parts: 1) an online survey of accepted male donors; 2) a qualitative evaluation with MSM donors and blood center staff; and 3) the development of a behavioral inventory to identify questions that distinguish high- from low-risk men who have sex with men.

Active Funding

2UM1A069470 (Hammer/El-Sadr, subcontract to Tieu), 12/1/2013 - 11/30/2020, “Columbia Partnership for Prevention and Control of HIV/AIDS Clinical Trials Unit”5UM1AI068614 (Corey, subcontract to Tieu), 12/1/2016 – 11/30/2018, “HVTN 704/HPTN 085 Protocol Funding (PF)” and “HVTN 704/HPTN 085 AMP Study Social and Behavioral Sciences Supplement: Enhancing Enrollment and Retention in US Phase II Clinical Trials– AMP Supplement Project”

2UM1AI068614 (Corey, subcontract to Tieu), 12/1/2016 – 11/30/2018, “Protocol Funds (PF):  HIV Vaccine Trials Network (HVTN),” “Scientific Leadership,” “HIV Vaccine Trials Network (HVTN) RAMP Program”

UM1 AI068619 (Cohen, subcontract to Tieu), 1/1/2017 – 12/31/2021, “HIV Prevention Trials Network (HPTN) 083”

1R56MH112401-01A1 (PI Tieu), 9/1/2017 – 8/31/2018, “Influence of Neighborhoods and Networks on the HIV Care Continuum among HIV-infected MSM in NYC”:

R34 MH108437-01A1 (PI Teitelman/Koblin, co-investigator Tieu), 08/05/2016 – 07/31/2019, “Developing a Women-Focused PrEP Intervention for HIV Prevention”

R01DA038108 (PI Frye), 9/2014-8/2018, "Testing an Intervention to Increase HIV Self-Testing among Young Black MSM"

R01HD078595 (PI Frye), 8/2013-3/2019, "Using technology to match young Black MSM to HIV testing options"    

Lab Personnel

  • Eddie Bravo, AS, Recruitment Associate
  • Tarashon Broomes, DNP, APRN, AGNP-C, Research Clinician
  • Nikki Englert, Research Counselor
  • Jay Loeffel, MEd, MPA, Senior Administrator
  • Angela Lomax, BSN, Clinician
  • Debbie Lucy, MS, Director of Clinical Studies
  • Ashton McGown, BS, Program Coordinator
  • Geneva Ortiz, AA, Senior Project Associate
  • Kiwan Stewart, BPS, Senior Counselor
  • DaShawn Usher, BS, Manager – Community Engagement
  • Tasha Vazquez, BS, Administrator

Education and Training

Doctoral Training
MD, Mount Sinai School of Medicine
MS, Epidemiology, Columbia University Mailman School of Public Health

Postdoctoral Training
Internal medicine residency, Department of Medicine, Boston University Medical Center
Infectious diseases fellowship, Division of Infectious Diseases/Department of Medicine, Columbia University Medical Center
Infectious disease epidemiology research fellowship, Center for Infectious Disease Epidemiologic Research, Columbia University Mailman School of Public Health

Publications

https://www.ncbi.nlm.nih.gov/sites/myncbi/hongvan.tieu.1/bibliography/41350201/public/?sort=date&direction=ascending

Key Publications

Mayer KH, Seaton KE, Huang Y, Grunenberg N, Isaacs A, Allen M, Ledgerwood JE, Frank I, Sobieszczyk ME, Baden LR, Rodriguez B, Tieu HV, Tomaras GD, Deal A, Goodman D, Bailer RT, Ferrari G, Jensen R, Hural J, Graham BS, Mascola JR, Corey L, Montefiori DC2; HVTN 104 Protocol Team; and the NIAID HIV Vaccine Trials Network. PLoS Med 2017;14(11):e1002435. doi:10.1371/journal.pmed.1002435. PMC5685476 

Li SS, Kochar NK, Elizaga M, Hay CM, Wilson GJ, Cohen KW, De Rosa SC, Xu R, Ota-Setlik A, Morris D, Finak G, Allen M, Tieu HV, Frank I, Sobieszczyk ME, Hannaman D, Gottardo R, Gilbert PB, Tomaras GD, Corey L, Clarke DK, Egan MA, Eldridge JH, McElrath MJ, Frahm N; NIAID HIV Vaccine Trials Network. DNA priming increases frequency of T-cell responses to a VSV HIV vaccine with specific enhancement of CD8+ T-cell responses by IL-12 pDNA. Clin Vaccine Immunol 2017. pii: CVI.00263-17. doi: 10.1128/CVI.00263-17. PMC5674193

Richardson S, Seekaew P, Koblin B, Vazquez T, Nandi V, Tieu HV. Barriers and facilitators of HIV vaccine and prevention study participation among Young Black MSM and transwomen in New York City. PLoS One 2017;12(7):e0181702. doi: 10.1371/journal.pone.0181702. eCollection 2017. PMC5517061 

Markowitz M, Frank I, Grant RM, Mayer KM, Elion R, Goldstein D, Fisher C, Sobieszczyk ME, Gallant JE, Tieu HV, Weinberg W, Margolis DA, Hudson KJ, Stancil BS, Ford SL, Patel P, Gould E, Rinehart, AR, Smith KY. Spreen W. ECLAIR: a randomised phase IIa safety and pharmacokinetic study of cabotegravir long-1 acting injection 800 mg every 12 weeks in HIV-uninfected men. Lancet Infectious Diseases 2017;4(8):e331-e340. doi: 10.1016/S2352-3018(17)30068-1.

Frye V, Nandi V, Egan JE, Cerda M, Rundle A, Quinn JW, Sheehan D, Ompad DC, Tieu HV, Greene E, Koblin B. Associations Among Neighborhood Characteristics and Sexual Risk Behavior Among Black and White MSM Living in a Major Urban Area. AIDS Behav 2016; 21(3):870-890. doi: 10.1007/s10461-016-1596-2.

Tieu HV, Nandi V, Hoover DR, Lucy D, Stewart K, Frye V, Cerda M, Ompad D, Latkin C, Koblin BA on behalf of the NYC M2M Study Team. Do Sexual Networks of Men Who Have Sex with Men in New York City Differ by Race/Ethnicity? AIDS Patient Care and STDs 2016: 30(1):39-47. doi:10.1089/apc.2015.0237. PMC4717505.

Tieu HV, Liu TY, Hussen S, Connor M, Wang L, Buchbinder S, Wilton L, Gorbach P, Mayer K, Griffith S, Kelly C, Elharrar V, Phillips G, Cummings V, Koblin B, Latkin C; HPTN 061. Sexual Networks and HIV Risk among Black Men Who Have Sex with Men in 6 U.S. Cities. PLoS ONE 2015: 10(8):e0134085. doi: 10.1371/journal.pone.0134085. PMC4524662. 

Tieu HV, Nandi V, Frye V, Stewart K, Oquendo H, Bush B, Cerda M, Hoover DR, Ompad D, Koblin BA. Concurrent Partnerships and HIV Risk among Men Who Have Sex with Men in New York City. Sexually Transmitted Diseases 2014:41(3):200-8. 

Tieu HV, Rolland M, Hammer S, Sobieszczyk ME. Translational Research Insights from Completed HIV Vaccine Efficacy Trials. JAIDS 2013:63 Suppl 2:S150-4. 

Tieu HV, Li X, Donnell D, Vittinghoff E, Buchbinder S, Parente ZG, Koblin BA. Anal Sex Role Segregation and Versatility among Men Who Have Sex with Men: EXPLORE Study. JAIDS 2013;64(1):121-125. PMC3804162.

26.     Edwards-Jackson N, Phanuphak N, Tieu HV, Chomchey N, Teeratakulpisarn N, Sathienthammawit W, Pakam C, Pharachetsakul N, Sobieszczyk ME, Phanuphak P, Ananworanich J. HIV Serostatus Disclosure is Not Associated with Safer Sexual Behavior among HIV-positive Men Who Have Sex with Men and Their Partners at Risk for Infection in Bangkok, Thailand. AIDS Research and Therapy 2012;9(1):38. PMC3537734.  

Tieu HV, Spikes P, Patterson J, Bonner S, Egan JE, Goodman K, Stewart K, Frye V, Xu G, Hoover DR, Koblin BA. Sociodemographic and Risk Behavior Characteristics Associated with Unprotected Sex with Women among Black Men Who Have Sex with Men and Women in New York City. AIDS Care 2012;24(9):1111-9.   

Tieu HV, Xu G, Bonner S, Spikes P, Egan JE, Goodman K, Stewart K, Koblin BA. Sexual Partner Characteristics, Serodiscordant/Serostatus Unknown Unprotected Anal Intercourse and Disclosure among HIV-infected and Uninfected Black Men Who Have Sex with Men in New York City. Sexually Transmitted Diseases 2011;38(6):548-54.

Tieu HV, Murrill C, Xu G, Koblin BA.  Sexual Partnering and HIV Risk among Black Men Who Have Sex With Men: New York City. Journal of Urban Health 2010;87:113-21.