Karina Yazdanbakhsh, PhD

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Title

Executive Director and Member, Lindsley F. Kimball Research Institute
Head, Laboratory of Complement Biology

Research Area

Transfusion immunology
We are studying cellular immune responses to transfused blood products with the goal of developing strategies to prevent immune-mediated transfusion reactions.  Current research focus is on characterizing immunoregulatory networks that result in development of antibodies (alloimmunization) against transfused cells in transfusion-dependent patients with sickle cell anemia (SCA) and thalassemia. 

Platelet autoimmunity
We are characterizing the cellular and molecular pathways resulting in platelet autoimmunity in patients with immune thrombocytopenia (ITP) with the goal of developing new and improved treatments. Current research focus is on identifying immunological signatures of ITP drug response.  

Contact Information

Email: KYazdanbakhsh@nybc.org
Phone: +1 (212) 570-3383

Lab Personnel

  • Giulia Calenda, PhD, Assistant Member
  • Avital Mendelson, PhD, Assistant Member
  • Guillermo Villegas, PhD, Research Associate

  • Yunfeng Liu, PhD, Research Fellow
  • Erika Choi, Research Assistant
  • Weili Bao, MS, Associate Lab Manager

Funding Support

  • NIH R01 HL130139 Yazdanbakhsh (PI) 5/1/2016-1/31/2021 "Mechanisms Controlling Transfusion-Associated Antibody Responses in SCD Alloimmunization
  • NIH R01 HL121415 Yazdanbakhsh (PI) 8/1/2014-4/30/2018 “T cell immunoregulation of alloimmunization in sickle cell Disease”

  • NIH R01 HL122788 Yazdanbakhsh (PI) 09/01/2015-03/31/2019 “Immunopathology of ITP”

  • American Heart Association  Yazdanbakhsh (PI) 07/01/2014-06/30/2017 “Immunological Characterization of Transfusion dependent Patients with Sickle Cell Disease”

Education and Training

Doctoral Training
PhD, Molecular Biology, National Institute for Medical Research (MRC), Mill Hill, London, UK 

Postdoctoral Training
Columbia University, Rockefeller University

LIST OF PUBLICATIONS