NYBC's world-renowned laboratories help medical professionals around the world solve problems related to patient antibodies, blood typing, antigens, and much more.
- National Center for Blood Group Genomics
Built on a foundation of innovation and discovery and combining the scientific and research expertise of New York Blood Center and Community Blood Center of Kansas City, the National Center for Blood Group Genomics (NCBGG) specializes in applying precision medicine to blood transfusion to increase safety and minimize complications. Based in Kansas City, NCBGG’s mission is to provide the highest quality testing services for extended blood typing at lower cost for donor centers and the patients they serve to improve the practice of transfusion medicine, to develop the next generation of testing, and to train the next generation of leaders.
National Center for Blood Group Genomics
2002 West 39th Ave
Kansas City, KS 66103
Phone: 1-844-NAT-GENO (1-844-628-4366)
- NYBC Blood Group Genomics
NYBC’s Genomics Laboratory provides two DNA-based typing services:
- Testing for RBC antigens
- Testing for platelet and neutrophil antigens
Under the guidance of Laboratory Manager Sunitha Vege, MS, the laboratory uses methods that include DNA array, PCR-RFLP, AS-PCR and gene specific amplification and sequencing, mRNA isolation, and cDNA sequencing when the situation arises. All results are reviewed in the context of serology and genomics at multiple levels to ensure that you receive information and clinical guidance for every situation.
GENOMICS TESTING SERVICES
- Red cell phenotyping based on genetics
- ABO genotyping and subgroup investigation
- RHD genotyping, including weak D, partial D, and zygosity
- RHCE genotyping, including partial, altered, or silenced Cc or Ee
- Null phenotypes in any blood group system
- New antigen investigation
- Platelet (HPA) typing, including HPA 1 through 9, 11, and 15
- Neutrophil (HNA) typing (HNA-3a/b)
DNA TESTING INDICATIONS
- Obtain extensive antigen profile on:
- Recently transfused patients
- Patients with positive direct antiglobulin tests (DAT)
- Patients with warm autoantibodies
- Patients with sickle cell disease or thalassemia
- Patients who have been transfused and developed an antibody
- Patients needing long-term transfusion support
- Patients whose RBCs demonstrate spontaneous agglutination
- Resolution of complex antibody identification and/or distinguish allo from autoantibody
- Resolution of ABO or Rh typing discrepancies
- Confirmation of weak or partial D phenotypes in women of childbearing age to guide transfusion and/or RhIG administration
- Identification of antigen-negative donor units if antisera is unavailable or limited in supply
- Typing of panel cells for uncommon or weakly expressed antigens
- Identification of novel antigens or phenotypes
- Testing for platelet antigens and post-transfusion purpura (PTP)
FETAL OR NEONATAL TESTING
- Evaluation of fetal risk for hemolytic disease of the fetus or newborn (HDFN) due to maternal antibodies to red cell antigens
- Evaluation of fetal risk for alloimmune thrombocytopenia (NAIT) due to maternal antibodies to platelet antigens
- Confirmation of maternal type, paternal zygosity, and fetal type
PLATELET ANTIGEN TYPING
Genomic DNA testing can improve platelet typing accuracy, help select compatible donors, aid the management and treatment for platelet destruction, and improve transfusion safety and outcomes for patients.
- Testing for platelet antigens and post-transfusion purpura (PTP)
- Evaluation of fetal risk for alloimmune thrombocytopenia (NAIT) due to maternal antibodies to platelet antigens including:
- Determining maternal and paternal HPA type
- Typing of fetal amniocytes or chorionic villus sample (CVS)
TYPING FOR THE FOLLOWING PLATELET ANTIGENS IS AVAILABLE
- HPA-1a/1b (PLA)
- HPA- 2a/2b (Ko)
- HPA-3a/3b (Bak)
- HPA -4a/4b (Pen)
- HPA-5a/5b (Br)
- HPA-15a/15b (Gov)
- HPA Array Panel: includes HPA 1 through 9, 11, and 15
PLATELET ANTIBODY SCREENING AND PLATELET CROSS MATCH
NYBC offers platelet antibody screening and platelet cross matching to supply compatible single donor platelet pheresis to the patient who has become refractory to random donor platelets and platelet pheresis products. Immune destruction of platelets can occur in patients with selected hematologic disorders (leukemia, systemic lupus erythematosis, and other collagen-vascular diseases). In vitro antibody screening tests detect the presence of these antibodies in patient (or donor) sera.
WANT MORE INFORMATION?
- Fred H. Allen Laboratory of Immunogenetics (HLA)
NYBC's Laboratory of Immunogenetics, under the direction of Carmelita Carrier, PhD (firstname.lastname@example.org), provides HLA testing for:
- Potential bone marrow and cord blood recipients
- Potential cord blood and bone marrow donors (families and unrelated)
- Platelet recipients and donors
- Verification of HLA typing for patients, donors and cord blood unit contiguous segment
- Disease risk, drug hypersensitivity reaction risk, vaccine eligibility assessment, clinical trials, etc.
The laboratory employs DNA-based methodologies for the detection of Human Leukocyte Antigens (HLA). These include determination of allele assignments by Sequence Based Typing (SBT), reverse Sequence Specific Oligonucleotide (rSSO) and Sequence Specific Primers (SSP).
The laboratory offers consultation directly with the physicians and blood bank staff for review of test results, sample and test requirements, and shipping arrangements.
Molecular HLA Tests Provided:
- HLA Class I (A,B,C) low / intermediate resolution
- HLA Class I (A,B,C) high resolution sequencing
- HLA Class II (DRB1, DQB1, DPB1) low / intermediate resolution
- HLA Class II (DRB1, DQB1, DPB1) high resolution sequencing
Want more information?
Laboratory of Immunogenetics 718.752.4717
- Immunohematology & Genomics
NYBC's Laboratories of Immunohematology and Blood Group Genomics provide two main services:
- Reference laboratory testing and consultation to assist in resolving patient antibody problems.
- Providing specialized blood products for transfusion.
The laboratories, under the direction of Connie Westhoff, SBB, PhD (email@example.com), receive more than 2,000 requests annually from hospitals and blood centers nationwide for help in identifying antibodies, and ongoing requests for assistance in matching donors to patients. The Laboratory also actively screens samples to identify donors whose red blood cells lack a high prevalence antigen or have uncommon blood group combinations.
These laboratories combine state-of-the-art methods in serological investigation and DNA blood group analysis to resolve complex cases, determine clinical significance, and provide consultation for selection of blood for transfusion.
Ask us how we can:
- Improve your blood typing accuracy
- Optimize compatible donor selection
- Aid the management and treatment of neonatal and fetal red cell or platelet destruction
- Improve transfusion safety and outcomes for patients
WANT MORE INFORMATION?
Immunohematology: 718.752.4771 or firstname.lastname@example.org
Blood Group Genomics: 718.752.4637 or email@example.com
Frozen Blood and Washed Products: 718.752.4633
We are known worldwide for expertise in resolving complex antibody investigations, with one of the most extensive collections of well-characterized red cells and antisera and one of the largest inventories of liquid and frozen donor units to support patients who need antigen-negative units for transfusion.
The laboratory, under the technical direction of Christine Lomas-Francis, MSc, FIBMS, and Helene DePalma, MT(ASCP) SBB, CQA (ASQ), Director of Operations and Quality, consists of a highly trained and experienced professional staff knowledgeable in immunohematology and genetics.
IMMUNOHEMATOLOGY TESTING SERVICES
- Resolution of complex red cell alloantibody problems
- Hemolytic Anemia investigation
- Warm and cold autoantibodies
- Transfusion reaction investigation
- Hemolytic disease of the fetus and newborn
- Direct antiglobulin test
- Antibody titrations (prenatal and cold agglutinin)
- ABO and D discrepancy resolution
- Adsorption and elution
- Donath-Landsteiner test
New Program Initiative: NYBC Helps You Be Redi to Reduce Alloimmunization
- Extensive inventory of antigen-negative RBC products
- RBC products typed for additional antigens such as CW, Jsa, Kpa, Lea, M, V, VS, Wra and DAK
- High volume donor testing for RBC products in partnership with Genomics providing RBC products typed for Doa, Dob, hrB, hrS, HY, Joa, and U
- Participate in the American Rare Donor Program (ARDP) to find rare blood that cannot be found locally
- RediLab™ and Redi-Kit Sample Shipping Program
Redilab is an online process for hospital staff users to order, track and access report results for Immunohematology, Genomics and HLA testing via a secure portal using barcoded identification while utilizing our proprietary RediKit sample shipping process.